Intervention studies

lifestyle intervention studies

Two European-wide intervention studies to reduce the impact of Endocrine Disruptors in sensitive populations

HYPIEND project will conduct two European-wide clinical studies in pregnant women and their infants, and pre-pubertal children to minimise exposure to EDCs and assess the applicability of the identified biomarkers in computer-modelling and laboratory studies.

The studies will evaluate the effectiveness of a multicomponent behavioural intervention featuring workshops and harnessing a mobile app to diminish levels of exposure to EDCs in pregnant and breastfeeding women and their children up to 18 months after birth and 6-8-year-old children.



A holistic approach to evaluate the effect of EDCs on the hypothalamus - pituitary axis

Behavioural change platform

Mobile App providing recommendations to limit EDC exposure in everyday life through gamification.

Educational workshops

Events to increase the knowledge on the hazards posed by EDCs and minimise exposure to these chemicals during critical development stages.

School educational programme

Creation of a school-wide EDC-free culture with school staff and delegates with specific actions limiting the usage of hazardous chemicals in educational centres.

Intervention in the first 1000 days

Pregnant and breastfeeding women, and their offspring up to 18 months

Randomized controlled trial conducted to test the effectiveness of a multicomponent behavioural intervention carried out at healthcare centres to reduce the concentrations of different EDCs in different fluids collected from pregnant women (urine, blood, breast milk) and their offspring (urine and cord blood) at different time points.

The study will also evaluate whether the intervention is able to prevent the harmful health effects associated to exposure to EDCs such as impairment in infant growth, behaviour, and neurodevelopment.

Study location

Spain, Belgium, and Poland


810 pregnant women and their infants

Intervention in pre-pubertal children

Children aged 6-8 years old, parents, and schools

Two-arm cluster randomized controlled trial consisting of an intervention in primary schools to assess its effectiveness in reducing the EDC exposure levels by measuring exposure biomarkers in children’s urine and prevent the advancement of puberty onset associated to a high exposure to EDCs.

The study, to be deployed during 3 years, aims also to increase parents’ knowledge regarding these chemicals.

Study location

Spain and Belgium


700 prepubertal children aged 6-8 and their parents