Intervention studies
lifestyle intervention studies
Two European-wide intervention studies to reduce the impact of Endocrine Disruptors in sensitive populations
HYPIEND project will conduct two European-wide clinical studies in pregnant women and their infants, and pre-pubertal children to minimise exposure to EDCs and assess the applicability of the identified biomarkers in computer-modelling and laboratory studies.
The intervention studies will evaluate the effectiveness of a multicomponent behavioural intervention featuring workshops and harnessing a mobile app to diminish levels of exposure to EDCs in pregnant and breastfeeding women and their children up to 18 months after birth and 6-8-year-old children.


INTERVENTION COMPONENTS
A holistic approach to evaluate the effect of EDCs on the hypothalamus - pituitary axis
Behavioural change platform
Educational workshops
School educational programme








Intervention STUDIES in the first 1000 days
Pregnant and breastfeeding women, and their offspring up to 18 months
Randomized controlled trial conducted to test the effectiveness of a multicomponent behavioural intervention carried out at healthcare centres to reduce the concentrations of different EDCs in different fluids collected from pregnant women (urine, blood, breast milk) and their offspring (urine and cord blood) at different time points.
The study will also evaluate whether the intervention is able to prevent the harmful health effects associated to exposure to EDCs such as impairment in infant growth, behaviour, and neurodevelopment.
Study location
Spain, Belgium, and Poland
Participants
810 pregnant women and their infants
Intervention in pre-pubertal children
Children aged 6-8 years old, parents, and schools
Two-arm cluster randomized controlled trial consisting of an intervention in primary schools to assess its effectiveness in reducing the EDC exposure levels by measuring exposure biomarkers in children’s urine and prevent the advancement of puberty onset associated to a high exposure to EDCs.
The study, to be deployed during 3 years, aims also to increase parents’ knowledge regarding these chemicals.
Study location
Spain and Belgium
Participants
700 prepubertal children aged 6-8 and their parents





